From Clinical Trials to Clinical Practice: Why the Gap?
نویسندگان
چکیده
منابع مشابه
From clinical trials to clinical practice: why the gap?
Based on an analysis of National Health and Nutrition Examination Survey data, the prevalence of hypertension in the United States increased from 25.0% in 1988 to 1991 to 28.7% in 1999 to 2000.1 Despite compelling evidence for the cardiovascular and renal benefits of hypertension control, during that same decade, hypertension control rates increased from 24.6% to only 31.0%. At a time when he w...
متن کاملGap between clinical trials and clinical practice: lessons from the Bypass Angioplasty Revascularization Investigation (BARI).
McGuire and colleagues 1 present interesting data and a careful analysis of how physicians respond to clinical trial results. Utilizing data from the National Cardiovascular Network and surveys of investigators at 13 sites, the authors considered the impact of the original Bypass Angioplasty Revascularization Investigation (BARI) randomized trial results,2 and the National Heart, Lung, and Bloo...
متن کاملDrotrecogin alfa (activated): diffusion from clinical trials to clinical practice.
BACKGROUND AND OBJECTIVE Although the PROWESS trial demonstrated a mortality benefit, subsequent studies in different patient populations have not reproduced the effect. As a result, concerns have been expressed about the clinical effectiveness of drotrecogin alfa (activated). Therefore the aim of this audit was to review the clinical impact of drotrecogin alfa (activated) when used outside cli...
متن کاملPrinciples from clinical trials relevant to clinical practice: Part II.
Principle 7: Most Therapies Produce a Combination of Helpful and Harmful Effects As therapies have become more biologically potent, it has become increasingly clear that every treatment can be harmful in some patients while being beneficial in others, and often both good and bad effects occur in the same patient. With many therapies, clinical characteristics can identify patients with greater e...
متن کاملPrinciples from clinical trials relevant to clinical practice: Part I.
The first 2 parts of this review discussed lessons learned from cardiovascular clinical trials about the design and interpretation of clinical trials. In the next 2 parts, we will attempt to apply these lessons to decision-making in clinical practice. We undertake this effort with trepidation, recognizing that translating research findings into the care of an individual patient is a frontier th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2006
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000229712.18111.b3